Homologous interference of lymphocytic choriomeningitis virus: detection and measurement of interference focus-forming units.

Inhibition of immunologic injury of cultured cells infected with lymphocytic choriomeningitis virus: role of defective interfering virus in regulating viral antigenic expression

The expression of viral antigens on the surfaces of lymphocytic choriomeningitis virus (LCMV)-infected L-929 cells peaked 2-4 days postinfection and thereafter precipitously declined. Little or no viral antigen was expressed on the plasma membrane surfaces of persistently infected cells, but LCMV antigens were clearly present in the cytoplasms of most of those cells. Cells early after acute inf...

An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis.

Previous studies have documented that, in the presence of the mutagenic base analogue 5-fluorouracil (FU), lymphocytic choriomeningitis virus (LCMV) that persisted in BHK-21 cells decreased its infectivity to a larger extent than intracellular viral RNA levels, prior to virus extinction. This observation, together with in silico simulations, led to the proposal of the lethal defection model of ...

Immunization of Guinea Pigs against Lymphocytic Choriomeningitis with Formolized Tissue Vaccines

Guinea pigs can be immunized against lymphocytic choriomeningitis by 2 or 3 injections with formolized vaccines prepared from a variety of infected guinea pig tissues. Vaccines prepared from the consolidated areas of diseased lungs gave the best results. The immunity produced was partial in the majority of the cases, in that the vaccinated animals as a rule showed fever after the test of immuni...

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.

Lymphocytic choriomeningitis virus (LCMV), strain WE, is a non-cytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus spread, followed by cytotoxic T lymphocyte-mediated virus clearance below the detection levels of conventional assays within 2-3 weeks. Indirect evidence had suggested that virus or viral antigen might...

Infectious Bronchitis virus interference with Growth of Newcastles disease virus. 1 - Study of interference in chicken embryos